1,2-Bis (2-iodoethoxy) ethane
1,2-Bis (2-iodoethoxy) ethane is a PEG-based PROTAC linker. 1,2-Bis (2-iodoethoxy) ethane can be used in the synthesis of MT802 and SJF620 (HY-133137). MT-802 and SJF620 are potent PROTAC BTK degraders with DC50s of 1 nM and 7.9 nM, respectively[1].
Product Specifications
CAS Number
36839-55-1
UNSPSC
12352211
Hazard Statement
H315, H319, H335
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/1-2-bis-2-iodoethoxy-ethane.html
Purity
98.66
Solubility
10 mM in DMSO
Smiles
ICCOCCOCCI
Molecular Formula
C6H12I2O2
Molecular Weight
369.97
Precautions
H315, H319, H335
References & Citations
[1]Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30 (3) :126877.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PEG Linkers
Frequently Asked Questions
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