1,2-Bis (2-iodoethoxy) ethane

1,2-Bis (2-iodoethoxy) ethane is a PEG-based PROTAC linker. 1,2-Bis (2-iodoethoxy) ethane can be used in the synthesis of MT802 (HY-122562) and SJF620 (HY-133137) . MT-802 and SJF620 are potent PROTAC BTK degraders with DC50s of 1 nM and 7.9 nM, respectively[1].

Product Specifications

CAS Number

[36839-55-1]

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/1-2-bis-2-iodoethoxy-ethane.html

Purity

98.66

Solubility

10 mM in DMSO

Smiles

ICCOCCOCCI

Molecular Formula

C6H12I2O2

Molecular Weight

369.97

Precautions

H315, H319, H335

References & Citations

[1]Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30 (3) :126877.