HDDAH-1-IN-1
HDDAH-1-IN-1 (compound 8a) is a potent and selective non-amino acid catalytic site inhibitor of human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1), with a Ki of 18 μM. DDAH mediates ADMA metabolism, thereby regulating nitric oxide production in a variety of disease states[1][2].
Product Specifications
CAS Number
1229238-69-0
UNSPSC
12352211
Target
Dimethylargininase (DDAH) ; NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hddah-1-in-1.html
Solubility
10 mM in DMSO
Smiles
N=C(NCCOC)NCCCCN
Molecular Formula
C8H20N4O
Molecular Weight
188.27
References & Citations
[1]Lunk I, et al. Discovery of N- (4-Aminobutyl) -N'- (2-methoxyethyl) guanidine as the First Selective, Nonamino Acid, Catalytic Site Inhibitor of Human Dimethylarginine Dimethylaminohydrolase-1 (hDDAH-1) . J Med Chem. 2019 Dec 31.|[2]Tran CT, et al. The DDAH/ADMA/NOS pathway. Atheroscler Suppl. 2003 Dec;4 (4) :33-40.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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