Afatinib N-Oxide
Afatinib N-Oxide is an impurity of Afatinib dimaleate in oxidative degradation. Afatinib dimaleate is an irreversible EGFR family inhibitor[1].
Product Specifications
CAS Number
[2413212-11-8]
UNSPSC
12352005
Target
Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/afatinib-n-oxide.html
Solubility
10 mM in DMSO
Smiles
ClC1=C(F)C=CC(NC2=NC=NC3=C2C=C(NC(/C=C/C[N+](C)([O-])C)=O)C(O[C@H]4CCOC4)=C3)=C1
Molecular Formula
C24H25ClFN5O4
Molecular Weight
501.94
References & Citations
[1]Pawan kumar, et al. A controlled, efficient and robust process for the synthesis of an epidermal growth factor receptor inhibitor: Afatinib Dimaleate. Chem Rep, 2019, 1 (1) : 3-12.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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