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Phrixotoxin-1 (TFA)

Phrixotoxin-1 (TFA), from the venom of the theraphosid spider Phrixotrichus auratus, is a specific peptide inhibitor of Kv4 potassium channel[1][2].

Product Specifications

UNSPSC

12352209

Target

Potassium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/phrixotoxin-1-tfa.html

Purity

96.46

Solubility

H2O : ≥ 100 mg/mL

Smiles

OC1=CC=C(C[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC2=CNC3=CC=CC=C23)C(N[C@H]4[C@@H](C)O)=O)=O)CCSC)=O)CC5=CNC6=CC=CC=C56)=O)CCCCN)=O)CCC(N)=O)=O)CSSC[C@H](NC7=O)C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]8CC9=CNC%10=CC=CC=C9%10)=O)CC(C)C)=O)CCCNC(N)=N)=O)CSSC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]7CSSC[C@H](NC8=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]([C@H](CC)C)C(N)=O)=O)[C@H](CC)C)=O)CCCCN)=O)CCCCN)=O)=O)CCCCN)=O)CCCNC(N)=N)=O)C)=O)CO)=O)CC(O)=O)=O)NC4=O)=O)C(C)C)=O)CC(C)C)=O)=O)CCC(O)=O)=O)=O)N)C=C1.OC(C(F)(F)F)=O.[x]

Molecular Formula

C156H240N44O37S7.xC2HF3O2

Molecular Weight

3548.30 (free base)

References & Citations

[1]Benjamin Chagot, et al. Solution structure of Phrixotoxin 1, a specific peptide inhibitor of Kv4 potassium channels from the venom of the theraphosid spider Phrixotrichus auratus. Protein Sci. 2004, 13, 5. |[2]Grit Schaarschmidt, et al. Characterization of Voltage-Gated Potassium Channels in Human Neural Progenitor Cells. PLoS One. 2009, 4, 7.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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