(E) -5-Hydroxyferulic acid

(E) -5-Hydroxyferulic acid is the E-isomer of 5-Hydroxyferulic acid (HY-133068) . 5-hydroxyferulic acid is a hydroxycinnamic acid and is a metabolite of the phenylpropanoid pathway. 5-Hydroxyferulic acid is a precursor in the biosynthesis of sinapic acid and is also a COMT non-esterifed substrat[1][2][3].

Product Specifications

CAS Number

[110642-42-7]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

COMT

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/e-5-hydroxyferulic-acid.html

Solubility

10 mM in DMSO

Smiles

O=C(O)/C=C/C1=CC(OC)=C(O)C(O)=C1

Molecular Formula

C10H10O5

Molecular Weight

210.19

Precautions

H315, H319, H335

References & Citations

[1]Parvathi K, et al. Substrate preferences of O-methyltransferases in alfalfa suggest new pathways for 3-O-methylation of monolignols. Plant J. 2001 Jan;25 (2) :193-202.|[2]Maury S, et al. Tobacco O-methyltransferases involved in phenylpropanoid metabolism. The different caffeoyl-coenzyme A/5-hydroxyferuloyl-coenzyme A 3/5-O-methyltransferase and caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferase classes have distinct substrate specificities and expression patterns. Plant Physiol. 1999 Sep;121 (1) :215-24.|[3]Inoue K, et al. Substrate preferences of caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferases in developing stems of alfalfa (Medicago sativa L.) . Arch Biochem Biophys. 2000 Mar 1;375 (1) :175-82.