HCV-IN-7 (hydrochloride)

HCV-IN-7 hydrochloride is an orally active and potent pan-genotypic HCV NS5A inhibitor with IC50s of 3-47 pM. HCV-IN-7 hydrochloride shows a superior pan-genotypic profile and a good pharmacokinetic profile coupled with a favorable liver uptake. HCV-IN-7 hydrochloride has anti-viral activity[1].

Product Specifications

CAS Number

[1449756-87-9]

UNSPSC

12352005

Target

HCV

Type

Reference compound

Related Pathways

Anti-infection

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hcv-in-7-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

[H]Cl.[H]Cl.O=C([C@H](C(C)C)NC(OC)=O)N(CCC1)[C@@H]1C(N2)=NC=C2C3=CC(C=C4)=C(S3)C5=C4C=C(C6=CN=C([C@H]7N(C([C@H](C(C)C)NC(OC)=O)=O)CCC7)N6)C=C5

Molecular Formula

C40H50Cl2N8O6S

Molecular Weight

841.85

References & Citations

[1]Ramdas V, et al. Discovery and Characterization of Potent Pan-Genotypic HCV NS5A Inhibitors Containing Novel Tricyclic Central Core Leading to Clinical Candidate. J Med Chem. 2019 Dec 12;62 (23) :10563-10582.