Mcl-1 inhibitor 3

Mcl-1 inhibitor 3 (compound 1) is a highly potent and orally activate macrocyclic Mcl-1 inhibitor (Ki= 0.061 nM; IC50=19 nM in an OPM-2 cell viability assay) . Mcl-1 inhibitor 3 shows good pharmacokinetic properties and excellent in vivo efficacy without toxicity[1]..

Product Specifications

CAS Number

[2376774-73-9]

UNSPSC

12352005

Target

Bcl-2 Family

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mcl-1-inhibitor-3.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC(CCC2)=C(C=C1)[C@]2(CO3)CN(C[C@H]4[C@@H](CC4)[C@@H](OCCN5CC(F)(F)C5)/C=C/CCN(C)C6=O)C7=C3C=CC([C@@](O)(C(NS(=O)(N(C)C)=O)=O)C6)=C7

Molecular Formula

C40H52ClF2N5O7S

Molecular Weight

820.38

References & Citations

[1]Rescourio G, Discovery and in Vivo Evaluation of Macrocyclic Mcl-1 Inhibitors Featuring an α-Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere.J Med Chem. 2019 Nov 27;62 (22) :10258-10271.