Mcl-1 inhibitor 3
Mcl-1 inhibitor 3 (compound 1) is a highly potent and orally activate macrocyclic Mcl-1 inhibitor (Ki= 0.061 nM; IC50=19 nM in an OPM-2 cell viability assay) . Mcl-1 inhibitor 3 shows good pharmacokinetic properties and excellent in vivo efficacy without toxicity[1]..
Product Specifications
CAS Number
[2376774-73-9]
UNSPSC
12352005
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mcl-1-inhibitor-3.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC(CCC2)=C(C=C1)[C@]2(CO3)CN(C[C@H]4[C@@H](CC4)[C@@H](OCCN5CC(F)(F)C5)/C=C/CCN(C)C6=O)C7=C3C=CC([C@@](O)(C(NS(=O)(N(C)C)=O)=O)C6)=C7
Molecular Formula
C40H52ClF2N5O7S
Molecular Weight
820.38
References & Citations
[1]Rescourio G, Discovery and in Vivo Evaluation of Macrocyclic Mcl-1 Inhibitors Featuring an α-Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere.J Med Chem. 2019 Nov 27;62 (22) :10258-10271.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Mcl-1
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