RIP2 kinase inhibitor 1
RIP2 kinase inhibitor 1 (compound 11) is a potent and selective receptor interacting protein 2 (RIP2) kinase inhibitor with an IC50 of 0.03 μM for RIP2 FP. RIP2 kinase inhibitor 1 is used for autoinflammatory disorders[1].
Product Specifications
CAS Number
[2380028-10-2]
UNSPSC
12352005
Target
RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rip2-kinase-inhibitor-1-1.html
Solubility
10 mM in DMSO
Smiles
O[C@@H]1[C@H](C2)NC3=C(C(N)=O)C(C4=CC(N=CS5)=C5C=C4)=NN3C[C@H]2C1
Molecular Formula
C17H17N5O2S
Molecular Weight
355.41
References & Citations
[1]Haffner CD, et al. Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors.ACS Med Chem Lett. 2019 Oct 11;10 (11) :1518-1523.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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