KRAS G12C inhibitor 18

KRAS G12C inhibitor 18 is a potent and orally active KRAS G12C inhibitor. Anti-tumor activities[1].

Product Specifications

CAS Number

[2649788-45-2]

UNSPSC

12352005

Target

Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/kras-g12c-inhibitor-18.html

Solubility

10 mM in DMSO

Smiles

N#CC1=C(N)SC2=CC=CC(C3=C(F)C=C(C(N4[C@@](CN(CC4)C(C=C)=O)([H])CCO5)=O)C5=C3Cl)=C12

Molecular Formula

C25H20ClFN4O3S

Molecular Weight

510.97

References & Citations

[1]Serge Louis Boulet, et al. Kras g12c inhibitors. WO2021118877A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

K-Ras

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