(R) -Pomalidomide-pyrrolidine
(R) -Pomalidomide-pyrrolidine, a CRBN ligand, can be connected to the ligand for protein by a linker to form PROTACs.
Product Specifications
CAS Number
2418618-52-5
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/r-pomalidomide-pyrrolidine.html
Solubility
10 mM in DMSO
Smiles
O=C(N1C2C(NC(CC2)=O)=O)C3=CC=CC(N[C@@H]4CCNC4)=C3C1=O
Molecular Formula
C17H18N4O4
Molecular Weight
342.35
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Sun D, et al. Evaluation of the Small-molecule BRD4 Degrader CFT-2718 in Small-cell Lung Cancer and Pancreatic Cancer Models. Mol Cancer Ther. 2021 Aug;20 (8) :1367-1377.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
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