(R) -Pomalidomide-pyrrolidine

(R) -Pomalidomide-pyrrolidine, a CRBN ligand, can be connected to the ligand for protein by a linker to form PROTACs.

Product Specifications

CAS Number

[2418618-52-5]

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Ligands for E3 Ligase

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/r-pomalidomide-pyrrolidine.html

Solubility

10 mM in DMSO

Smiles

O=C(N1C2C(NC(CC2)=O)=O)C3=CC=CC(N[C@@H]4CCNC4)=C3C1=O

Molecular Formula

C17H18N4O4

Molecular Weight

342.35

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Sun D, et al. Evaluation of the Small-molecule BRD4 Degrader CFT-2718 in Small-cell Lung Cancer and Pancreatic Cancer Models. Mol Cancer Ther. 2021 Aug;20 (8) :1367-1377.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Cereblon

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