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ADAM8-IN-1

ADAM8-IN-1 is a potent ADAM8 inhibitor with an IC50 value of 73 nM.

Product Specifications

CAS Number

2758892-64-5

UNSPSC

12352005

Target

MMP

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/adam8-in-1.html

Purity

98.30

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NCCC[C@@H](NS(=O)(C1=CC=C(OCC2=CC(Br)=CC(Br)=C2)C=C1)=O)C(NO)=O)C3=CC=CC(C(NCCC[C@@H](NS(=O)(C4=CC=C(OCC5=CC(Br)=CC(Br)=C5)C=C4)=O)C(NO)=O)=O)=C3

Molecular Formula

C44H44Br4N6O12S2

Molecular Weight

1232.60

References & Citations

[1]Cuffaro D, et al. Discovery of Dimeric Arylsulfonamides as Potent ADAM8 Inhibitors. ACS Med. Chem. Lett. 2021, 12, 11, 1787–1793.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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