ADAM8-IN-1
ADAM8-IN-1 is a potent ADAM8 inhibitor with an IC50 value of 73 nM.
Product Specifications
CAS Number
[2758892-64-5]
UNSPSC
12352005
Target
MMP
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/adam8-in-1.html
Purity
98.30
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NCCC[C@@H](NS(=O)(C1=CC=C(OCC2=CC(Br)=CC(Br)=C2)C=C1)=O)C(NO)=O)C3=CC=CC(C(NCCC[C@@H](NS(=O)(C4=CC=C(OCC5=CC(Br)=CC(Br)=C5)C=C4)=O)C(NO)=O)=O)=C3
Molecular Formula
C44H44Br4N6O12S2
Molecular Weight
1232.60
References & Citations
[1]Cuffaro D, et al. Discovery of Dimeric Arylsulfonamides as Potent ADAM8 Inhibitors. ACS Med. Chem. Lett. 2021, 12, 11, 1787–1793.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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