RORγ agonist 1
RORγ agonist 1 is a potent and orally bioavailable RORγ agonist (EC50 = 21 nM) with antitumor activity.
Product Specifications
CAS Number
[2260631-91-0]
UNSPSC
12352005
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rorγ-agonist-1.html
Solubility
10 mM in DMSO
Smiles
FCCN1C2=CC=C(C(N[C@H](C3=CC=C(C=C3)S(CC)(=O)=O)CO)=O)C=C2C=C1CC4=C(C=C(C=C4)Cl)C(F)(F)F
Molecular Formula
C29H27ClF4N2O4S
Molecular Weight
611.05
References & Citations
[1]Lu B, et al. Discovery of 2- (Ortho-Substituted Benzyl) -Indole Derivatives as Potent and Orally Bioavailable RORγ Agonists with Antitumor Activity. J Med Chem. 2021 Oct 28;64 (20) :14983-14996.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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