PCSK9-IN-2

2099167-44-7

PCSK9-IN-2 is a novel small molecule inhibitor of PCSK9-LDLR protein–protein interaction (PPI) with an IC50 value of 7.57 μM.

PCSK9

Reference compound

Metabolic Enzyme/Protease

Neuroscience-Neuromodulation

Cardiovascular Disease

https://www.medchemexpress.com/pcsk9-in-2.html

10 mM in DMSO

O=C1NCCCC[C@H]1N[C@@H]2CC(N(C2=O)C3=CC=C(C=C3)N4C(C[C@H](C4=O)N[C@@H]5CCCCNC5=O)=O)=O

524.57

[1]Sun H, et al. Discovery of Novel Small Molecule Inhibitors Disrupting the PCSK9-LDLR Interaction. J Chem Inf Model. 2021 Oct 25;61(10):5269-5279.

Room temperature

No Development Reported