JNJ-67569762
Product Specifications
UNSPSC Description
JNJ-67569762 is a selective BACE1 inhibitor targeting the S3 pocket (IC50 = 2.7 nM).
Target Antigen
Beta-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/jnj-67569762.html
Solubility
10 mM in DMSO
Smiles
FC[C@]1(C2=CC(NC(C3=NC=C(OC(F)(O4)F)C4=C3)=O)=CC=C2F)N=C([C@@](C)(CC1)S(CC)(=O)=O)N
Molecular Weight
530.49
References & Citations
[1]Rombouts FJR, et al. JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate. J Med Chem. 2021 Oct 14;64(19):14175-14191.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-132895/JNJ-67569762-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-132895/
Clinical Information
No Development Reported
CAS Number
2380313-26-6
Curated Selection
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