JNJ-67569762
JNJ-67569762 is a selective BACE1 inhibitor targeting the S3 pocket (IC50 = 2.7 nM) .
Product Specifications
CAS Number
[2380313-26-6]
UNSPSC
12352005
Target
Beta-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/jnj-67569762.html
Solubility
10 mM in DMSO
Smiles
FC[C@]1(C2=CC(NC(C3=NC=C(OC(F)(O4)F)C4=C3)=O)=CC=C2F)N=C([C@@](C)(CC1)S(CC)(=O)=O)N
Molecular Formula
C22H22F4N4O5S
Molecular Weight
530.49
References & Citations
[1]Rombouts FJR, et al. JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate. J Med Chem. 2021 Oct 14;64 (19) :14175-14191.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BACE1
More Discoveries
Explore Other Products
Browse additional items from our catalog
![Topoisomerase II alpha (TOP2A) Mouse Monoclonal Antibody [Clone ID: OTI9E1]](https://cdn.genprice.uk/genprice/uk/genprice5.webp)
TA802499S 30 µL
Topoisomerase II alpha (TOP2A) Mouse Monoclonal Antibody [Clone ID: OTI9E1]
Sign In for Pricing
View Details NBP1-18951AF750 0.1 mL
Mouse Monoclonal HPx1 Antibody (HIC0-3B3) [Alexa Fluor 750]
Sign In for Pricing
View Details FY-EH2253 96 Well
Human Ctx-Iii (Cross Linked C-telopeptide of Type III Collagen) ELISA Kit
Sign In for Pricing
View Details