PDE4-IN-3
PDE4-IN-3 is a novel and orally active PDE4 inhibitor with potent inhibitory affinity (IC50 = 4.2 nM) .
Product Specifications
CAS Number
2755687-49-9
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/pde4-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(OC3=CC(OCC4=CC=C(C=C4)F)=C(C(C/C=C(C)\C)=C31)OC)C=C5OC(C)(C=CC5=C2OC/C=C/C(O)=O)C
Molecular Formula
C35H33FO8
Molecular Weight
600.63
References & Citations
[1]Huang YY, et al. Mangostanin Derivatives as Novel and Orally Active Phosphodiesterase 4 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis with Improved Safety. J Med Chem. 2021 Sep 23;64 (18) :13736-13751.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE4
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