SGI-1776
SGI-1776 is an inhibitor of Pim kinases, with IC50s of 7 nM, 363 nM, and 69 nM for Pim-1, Pim-2 and Pim-3, respectively[1][2][3][4].
Product Specifications
CAS Number
[1173928-26-1]
UNSPSC
12352005
Target
Apoptosis; Autophagy; Pim
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; JAK/STAT Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/sgi-1776-1.html
Solubility
10 mM in DMSO
Smiles
CN1CCC(CC1)CNC2=NN3C(C=C2)=NC=C3C4=CC=CC(OC(F)(F)F)=C4.O=S(O)(O)=O.O=S(O)(O)=O
Molecular Formula
C20H26F3N5O9S2
Molecular Weight
601.57
References & Citations
[1]Chen LS, et al. Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia. Blood, 2011, 118 (3), 693-702.|[2]Xie J, et al. SGI-1776, an imidazo pyridazine compound, inhibits the proliferation of ovarian cancer cells by inactivating Pim-1. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2014 Jul;39 (7) :649-57|[3]Park YK, et al. The novel anti-adipogenic effect and mechanisms of action of SGI-1776, a Pim-specific inhibitor, in 3T3-L1 adipocytes. Int J Mol Med. 2016 Jan;37 (1) :157-64|[4]Hou X, et al. Biochemical changes of salivary gland adenoid cystic carcinoma cells induced by SGI-1776. Exp Cell Res. 2017 Mar 15;352 (2) :403-411.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-13287A/SGI-1776-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-13287A/
Scientific Category
Reference compound1
Clinical Information
Phase 1
Curated Selection
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