Nezulcitinib
Nezulcitinib (TD-0903) is an inhaled and lung-selective pan-Janus kinase (JAK) inhibitor. Nezulcitinib can be used for the research of COVID-19 associated acute lung injury and impaired oxygenation[1][2].
Product Specifications
CAS Number
2412496-23-0
Product Name Alternative
TD-0903
UNSPSC
12352005
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nezulcitinib.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CC(C1)N(C)C)[C@@H]2CC3=C(CN2C(C)C)N=C(C4=NNC5=CC(C6=C(C=C(C=C6)O)CC)=CC=C45)N3
Molecular Formula
C30H37N7O2
Molecular Weight
527.66
References & Citations
[1]Theravance's nezulcitinib fails to meet Phase II goals in Covid-19|[2]Theravance biopharma, inc. Announces top-line results from phase 2 study of nezulcitinib in patients hospitalized with acute lung injury due to COVID-19
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
JAK
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