Nedosiran
Nedosiran (DCR-PHXC) is an RNA interference (RNAi) targeting lactate dehydrogenase (LDH) . Nedosiran represents an impactful potential therapeutic for primary hyperoxaluria (PH) with end-stage renal disease (ESRD) . Nedosiran is a GalNAc-dsRNA conjugate[1][2][3].
Product Specifications
CAS Number
2266591-83-5
Product Name Alternative
DCR-PHXC
UNSPSC
12352208
Target
Lactate Dehydrogenase; Small Interfering RNA (siRNA)
Type
Oligonucleotides
Related Pathways
Epigenetics; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/nedosiran.html
Solubility
10 mM in H2O
Smiles
[Nedosiran]
Molecular Formula
C662H865F19N231O413P57S6
Molecular Weight
20985.12
References & Citations
[1]Kevin Shee, et al. Nedosiran Dramatically Reduces Serum Oxalate in Dialysis-Dependent Primary Hyperoxaluria 1: A Compassionate Use Case Report. Urology.2021 Oct;156:e147-e149.|[2]Gema Ariceta, et al. Hepatic Lactate Dehydrogenase A: An RNA Interference Target for the Treatment of All Known Types of Primary Hyperoxaluria. Kidney Int Rep. 2021 Feb 3;6 (4) :1088-1098. |[3]Thomas A Forbes, et al. Therapeutic RNA interference: A novel approach to the treatment of primary hyperoxaluria. Br J Clin Pharmacol. 2021 May 22.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
Launched
Available Sizes
Frequently Asked Questions
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