AB-729 (sodium)
Product Specifications
UNSPSC Description
AB-729 sodium is a siRNA specifically designed to inhibit viral replication and reduces HBV antigens[1][2]. AB-729 conjugates to a trimer of N-acetylgalactosamine (GalNAc) ligand that promotes uptake into hepatocytes via the asialoglycoprotein receptor (ASGR).
Target Antigen
HBV; Small Interfering RNA (siRNA)
Type
Oligonucleotides
Related Pathways
Anti-infection;Epigenetics
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ab-729-sodium.html
Solubility
10 mM in H2O
Smiles
[AB-729 (sodium)]
Molecular Weight
16148.44
References & Citations
[1]Efthymios P Tsounis, et al. Toward a new era of hepatitis B virus therapeutics: The pursuit of a functional cure. World J Gastroenterol. 2021 Jun 7;27(21):2727-2757.|[2]Arbutus Receives Authorization to Proceed with an Investigational New Drug Application (IND) for AB-729, its Proprietary Subcutaneously-Delivered RNAi Agent.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-132603A/AB-729-sodium-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-132603A/
Clinical Information
Phase 2
CAS Number
2826248-50-2
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