LY2886721 (hydrochloride)
LY2886721 hydrochloride is a potent, selective and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 20.3 nM for recombinant human BACE1. LY2886721 hydrochloride is selectivity against cathepsin D, pepsin, and renin, but lacking selectivity against BACE2 (IC50 of 10.2 nM) . LY2886721 hydrochloride can across blood-brain barrier and has the potential for Alzheimer's disease treatment[1].
Product Specifications
CAS Number
1262036-49-6
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Beta-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ly2886721-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
FC1=CN=C(C=C1)C(NC2=CC=C(C([C@@]34[C@]([H])(CSC(N)=N4)COC3)=C2)F)=O.[H]Cl
Molecular Formula
C18H17ClF2N4O2S
Molecular Weight
426.87
Precautions
P261-P280-P302+P352
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Frequently Asked Questions
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