LY2886721 (hydrochloride)

LY2886721 hydrochloride is a potent, selective and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 20.3 nM for recombinant human BACE1. LY2886721 hydrochloride is selectivity against cathepsin D, pepsin, and renin, but lacking selectivity against BACE2 (IC50 of 10.2 nM) . LY2886721 hydrochloride can across blood-brain barrier and has the potential for Alzheimer's disease treatment[1].

Product Specifications

CAS Number

[1262036-49-6]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Beta-secretase

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ly2886721-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

FC1=CN=C(C=C1)C(NC2=CC=C(C([C@@]34[C@]([H])(CSC(N)=N4)COC3)=C2)F)=O.[H]Cl

Molecular Formula

C18H17ClF2N4O2S

Molecular Weight

426.87

Precautions

P261-P280-P302+P352

References & Citations

[1]May PC1, et al. The potent BACE1 inhibitor LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs, and humans. J Neurosci. 2015 Jan 21;35 (3) :1199-210.