ITK antagonist
ITK antagonist (compound 10 n) is a potent, orally active and selective ITK (Interleukin-2 inducible T-cell kinase) antagonist (IC50=1 and 20 nM in different assays) . ITK antagonist inhibits insulin receptor kinase (IRK) with an IC50 of 160 nM[1].
Product Specifications
CAS Number
1149753-56-9
UNSPSC
12352005
Target
Itk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/itk-antagonist.html
Solubility
10 mM in DMSO
Smiles
CC(C)(O)CN1C2=CC=C(CN[C@@H](C)C(C)(C)C)C=C2N=C1NC(C3=CC=C(C4=CNN=C4)S3)=O
Molecular Formula
C26H34N6O2S
Molecular Weight
494.65
References & Citations
[1]Riether D, et al. 5-Aminomethylbenzimidazoles as potent ITK antagonists. Bioorg Med Chem Lett. 2009;19 (6) :1588-1591.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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