PI3Kγ inhibitor 4
PI3Kγ inhibitor 4 is a potent, selective and orally active inhibitor of PI3Kγ, with an IC50 of 40 nM. PI3Kγ inhibitor 4 shows ～7, 43, and 18-fold selectivity for PI3Kγ over the α, β, and δ isoforms, respectively. PI3Kγ inhibitor 4 can be used for the research of airway inflammation[1].
Product Specifications
CAS Number
1821038-80-5
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pi3kγ-inhibitor-4.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=C(C)C(C2=CC(C3=CN=C(C)O3)=C(N)N=C2)=C1)(NCC(C)(O)C)=O
Molecular Formula
C20H24N4O4S
Molecular Weight
416.49
References & Citations
[1]Bellenie BR, et, al. Discovery and Toxicological Profiling of Aminopyridines as Orally Bioavailable Selective Inhibitors of PI3-Kinase γ. J Med Chem. 2021 Aug 26;64 (16) :12304-12321.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kα; PI3Kγ
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