(1S,3R) -GNE-502
(1S,3R) -GNE-502 (compound 179) is a potent ERα degrader with an EC50 value of 13 nM against ERα in MCF7 HCS. (1S,3R) -GNE-502 can be used to research cancer related with estrogen receptor[1].
Product Specifications
CAS Number
[1953134-15-0]
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/1s-3r-gne-502.html
Solubility
10 mM in DMSO
Smiles
C[C@@H]1CC(C2=CC=CC=C2N3)=C3[C@H](C4=CC=C(C=C4)OCCN5CC(C5)CF)N1S(=O)(C)=O
Molecular Formula
C25H30FN3O3S
Molecular Weight
471.59
References & Citations
[1]Simon Charles Goodacre, et al. Tetrahydro-Pyrido[3,4-b]Indole Estrogen Receptor Modulators And Uses Thereof. WO2016097072A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERα
Curated Selection
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