GSK040
GSK040 is a potent and highly selective BET BD2 inhibitor, with a pIC50 of 8.3. GSK040 shows more than 5000-fold selectivity for BET BD2 over BET BD1 (pIC50=4.6) . GSK040 can be used for the research of oncology and immunology diseases[1].
Product Specifications
CAS Number
2752331-09-0
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gsk040.html
Solubility
10 mM in DMSO
Smiles
O=C(C(C=C1C)=CN(C)C1=O)N([C@H](C2CCOCC2)C(NC)=O)C[C@H](C3=CC=CC=C3)C4=NC=CC=C4
Molecular Formula
C29H34N4O4
Molecular Weight
502.60
References & Citations
[1]Rianjongdee F, et, al. Discovery of a Highly Selective BET BD2 Inhibitor from a DNA-Encoded Library Technology Screening Hit. J Med Chem. 2021 Jul 12.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BD2
Frequently Asked Questions
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