Dimethylamiloride (hydrochloride)
Dimethylamiloride hydrochloride is a Na+/H+ exchanger NHE inhibitor with Ki values of 0.02, 0.25, and 14 μM for NHE1, NHE2, and NHE3, respectively. Dimethylamiloride hydrochloride can be used for pain research[1].
Product Specifications
CAS Number
[2235-97-4]
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Na+/H+ Exchanger (NHE)
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dimethylamiloride-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=NC(Cl)=C(N(C)C)N=C1N)NC(N)=N.Cl
Molecular Formula
C8H13Cl2N7O
Molecular Weight
294.14
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]Masereel B, et al. An overview of inhibitors of Na (+) /H (+) exchanger. Eur J Med Chem. 2003 Jun;38 (6) :547-54.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
J Dermatolog Treat. 2023 Dec;34 (1) :2220445.|Cell Metab. 2025 Sep 24:S1550-4131 (25) 00385-7.|Electrophoresis. 2025 Sep 23.
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