Seco-DUBA (hydrochloride)
Seco-DUBA hydrochloride is a toxin for ADC drug SYD985[1].
Product Specifications
CAS Number
1795733-93-5
UNSPSC
12352203
Target
ADC Payload
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/seco-duba-hydrochloride.html
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
ClC[C@H]1C2=C(C=C(C3=CC=CC(C)=C32)O)N(C1)C(C4=CN(C=C(C=C5)NC(C6=CC=C(C=C6)O)=O)C5=N4)=O.Cl[H].[x]
Molecular Formula
C29H23ClN4O4.xHCl
References & Citations
[1]Ronald C Elgersma, et al. Design, Synthesis, and Evaluation of Linker-Duocarmycin Payloads: Toward Selection of HER2-Targeting Antibody-Drug Conjugate SYD985. Mol Pharm. 2015 Jun 1;12 (6) :1813-35.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Frequently Asked Questions
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