MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin
MC-AAA-NHCH2OCH2COO-7-aminomethyl-10-methyl-11-fluoro camptothecin (compound 21a), a camptothecin payload, can be conjugated to a monoclonal antibody (mAb) for the synthesis of camptothecin antibody-drug conjugate (ADC) [1].
Product Specifications
CAS Number
[2414594-29-7]
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mc-aaa-nhch2och2coo-7-aminomethyl-10-methyl-11-fluoro-camptothecin.html
Purity
96.00
Solubility
DMSO : 100 mg/mL
Smiles
O=C(C=CC1=O)N1CCCCCC(N[C@@H](C)C(N[C@@H](C)C(N[C@@H](C)C(NCOCC(NCC2=C3C(C(N4C3)=CC([C@](O)(C(OC5)=O)CC)=C5C4=O)=NC6=CC(F)=C(C)C=C62)=O)=O)=O)=O)=O
Molecular Formula
C44H51FN8O12
Molecular Weight
902.92
References & Citations
[1]Li W, et, al. Synthesis and Evaluation of Camptothecin Antibody-Drug Conjugates. ACS Med Chem Lett. 2019 Sep 6;10 (10) :1386-1392.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Available Sizes
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