MTEP
MTEP is a potent, non-competitive and highly selective mGluR5 antagonist, with an IC50 of 5 nM and a Ki of 16 nM. MTEP shows antidepressant and anxiolytic-like effects. MTEP can be used for Parkinson's disease research[1][2][3][4]. MTEP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Product Specifications
CAS Number
329205-68-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mtep.html
Purity
99.91
Solubility
10 mM in DMSO
Smiles
CC1=NC(C#CC2=CC=CN=C2)=CS1
Molecular Formula
C11H8N2S
Molecular Weight
200.26
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR5
Citation 01
Psychopharmacology (Berl) . 2024 Jul;241 (7) :1399-1415.|Neurochem Int. 2024 Jun 4:178:105786.|Sci Adv. 2022 Aug 19;8 (33) :eabn7357.
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