Biperiden (lactate)

Biperiden (KL 373) lactate is an orally active non-selective muscarinic receptor antagonist that competitively binds to M1 muscarinic receptors. Biperiden (KL 373) lactate inhibits acetylcholine and enhances dopamine signaling in the central nervous system. Biperiden (KL 373) lactate has the potential for the research of Parkinson's disease and other related psychiatric disorders[1][2].

Product Specifications

CAS Number

[7085-45-2]

Product Name Alternative

KL 373 (lactate)

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

MAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/biperiden-lactate.html

Solubility

10 mM in DMSO

Smiles

OC(C1C2CC(C=C2)C1)(C3=CC=CC=C3)CCN4CCCCC4.OC(C(O)C)=O

Molecular Formula

C24H35NO4

Molecular Weight

401.54

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Leonie Konczalla, et al. Biperiden and mepazine effectively inhibit MALT1 activity and tumor growth in pancreatic cancer. Int J Cancer. 2020 Mar 15;146 (6) :1618-1630.|[2]Simone Bittencourt, et al. Modification of the natural progression of epileptogenesis by means of biperiden in the pilocarpine model of epilepsy. Epilepsy Res. 2017 Dec;138:88-97. doi: 10.1016/j.eplepsyres.2017.10.019. Epub 2017 Oct 29.