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SFTX-3.3

SFTX-3.3 is a Ca2+ channel antagonist with IC50s of approximately 0.24 mM and 0.70 mM against P-type and N-type channels[1][2].

Product Specifications

CAS Number

141997-14-0

UNSPSC

12352211

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sftx-3-3.html

Solubility

10 mM in DMSO

Smiles

O=C(NCCCNCCCN)[C@@H](N)CCCNC(N)=N

Molecular Formula

C12H29N7O

Molecular Weight

287.40

References & Citations

[1]Maria Elisa Calcagnotto, et al. An examination of calcium current function on heterotopic neurons in hippocampal slices from rats exposed to methylazoxymethanol. Epilepsia. 2003 Mar;44 (3) :315-21.|[2]T M Norris, et al. Block of high-threshold calcium channels by the synthetic polyamines sFTX-3.3 and FTX-3.3. Mol Pharmacol. 1996 Oct;50 (4) :939-46.|[3]M Fatehi, et al. Polyamine FTX-3.3 and polyamine amide sFTX-3.3 inhibit presynaptic calcium currents and acetylcholine release at mouse motor nerve terminals. Neuropharmacology. 1997 Feb;36 (2) :185-94.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

N-type calcium channel; P/Q-type calcium channel

Frequently Asked Questions

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