DAPM
DAPM is a Notch pathway inhibitor with anticancer activity and antiproliferative effects. DAPM effectively inhibits tubular adenoma development by inhibiting cell proliferation and inducing the expression of Krüppel-like factor 4 (KLF4) and p21 in human colon cancer cells[1].
Product Specifications
CAS Number
[208255-51-0]
UNSPSC
12352209
Target
Notch
Type
Peptides
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dapm.html
Solubility
10 mM in DMSO
Smiles
FC1=CC(F)=CC(CC(N[C@@H](C)C(N[C@@H](C2=CC=CC=C2)C(OC)=O)=O)=O)=C1
Molecular Formula
C20H20F2N2O4
Molecular Weight
390.38
References & Citations
[1]Miyamoto S, et al. Suppression of colon carcinogenesis by targeting Notch signaling. Carcinogenesis. 2013 Oct;34 (10) :2415-23.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-131923/DAPM-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-131923/
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
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