LpxC-IN-5
LpxC-IN-5 is a potent non-hydroxamate LpxC (UDP-3-O-acyl-N-acetylglucosamine deacetylase) inhibitor with an IC50 of 20 nM. LpxC-IN-5 shows antibacterial activity against E. coli ATCC25922, P. aeruginosa ATCC27853, K. pneumoniae ATCC13883 and P. aeruginosa 5567 with MIC of 16, 4, 64, and 4 μg/mL, respectively[1].
Product Specifications
CAS Number
[2253951-38-9]
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/lpxc-in-5.html
Solubility
10 mM in DMSO
Smiles
C[C@@H](C1=NC=CN1CC2=NOC(C#CC3=CC=C(C=C3)OCC(CO)(CO)N)=C2)O
Molecular Formula
C21H24N4O5
Molecular Weight
412.44
References & Citations
[1]Yamada Y, et al. Fragment-Based Discovery of Novel Non-Hydroxamate LpxC Inhibitors with Antibacterial Activity [published online ahead of print, 2020 Nov 19]. J Med Chem. 2020;10.1021/acs.jmedchem.0c01215.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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