VH032 amide-PEG1-acid
VH032 amide-PEG1-acid (linker 10) is a VHL-1 alkyl linker that can be used to bind CDK4/6 ligands (PI) and degradation/destruction tags (EL) (e.g., E3 ligase ligands) [1].
Product Specifications
CAS Number
2172820-07-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
DNA Alkylator/Crosslinker; E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vh032-amide-peg1-acid.html
Purity
97.12
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)NC(CCOCCC(O)=O)=O)=O)C[C@H](O)C3
Molecular Formula
C28H38N4O7S
Molecular Weight
574.69
Precautions
H302, H315, H319
References & Citations
[1]Jian Jin, et al. Compositions and methods for treating cdk4/6-mediated cancer. WIPO (PCT) . WO2018106870A1. 2018-06-14.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
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Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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