VH032 amide-PEG1-acid
VH032 amide-PEG1-acid (linker 10) is a VHL-1 alkyl linker that can be used to bind CDK4/6 ligands (PI) and degradation/destruction tags (EL) (e.g., E3 ligase ligands) [1].
Product Specifications
CAS Number
[2172820-07-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
DNA Alkylator/Crosslinker; E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/vh032-amide-peg1-acid.html
Purity
97.12
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)NC(CCOCCC(O)=O)=O)=O)C[C@H](O)C3
Molecular Formula
C28H38N4O7S
Molecular Weight
574.69
Precautions
H302, H315, H319
References & Citations
[1]Jian Jin, et al. Compositions and methods for treating cdk4/6-mediated cancer. WIPO (PCT) . WO2018106870A1. 2018-06-14.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Badge
Hot
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Polymerase DNA Directed Delta 1 (POLd), Recombinant, Mouse, His-Tag
Polymerase DNA Directed Delta 1 (POLd), Recombinant, Mouse, His-Tag