(±) 9,10-DiHOME

(±) 9,10-DiHOME is the racemate of 9,10-DiHOME. 9,10-DiHOME is a leukotoxin derivative of linoleic acid diol that has been reported to be toxic in human's tissue preparations, and is produced by inflammatory leukocytes such as neutrophils and macrophages[1].

Product Specifications

CAS Number

[263399-34-4]

UNSPSC

12352211

Hazard Statement

H225, H319, H336

Target

AP-1; NF-κB; PPAR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/racemic-9-10-dihome.html

Concentration

318 μM * 250 μL in Methyl acetate

Purity

99.90

Solubility

10 mM in DMSO

Smiles

CCCCC/C=C\CC(O)C(O)CCCCCCCC(O)=O

Molecular Formula

C18H34O4

Molecular Weight

314.46

Precautions

H225, H319, H336

References & Citations

[1]Nieman DC, et al. Influence of pistachios on performance and exercise-induced inflammation, oxidative stress, immune dysfunction, and metabolite shifts in cyclists: a randomized, crossover trial. PLoS One. 2014;9 (11) :e113725. Published 2014 Nov 19.