Valienamine

Valienamine is the alpha-glucosidase inhibitor. Valienamine is the key functional component of many natural glycosidase inhibitors including the crop protectant validamycin A and the antidiabetic agent acarbose[1].

Product Specifications

CAS Number

[38231-86-6]

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

Glycosidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/valienamine.html

Solubility

10 mM in DMSO

Smiles

O[C@@H]1[C@@H](O)[C@H](O)C(CO)=C[C@@H]1N

Molecular Formula

C7H13NO4

Molecular Weight

175.18

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Degwert U, et al. Studies on the biosynthesis of the alpha-glucosidase inhibitor acarbose: valienamine, a m-C7N unit not derived from the shikimate pathway. J Antibiot (Tokyo) . 1987;40 (6) :855-861.|[2]Cui L, et al. A Validamycin Shunt Pathway for Valienamine Synthesis in Engineered Streptomyces hygroscopicus 5008. ACS Synth Biol. 2020;9 (2) :294-303.