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Digoxigenin bisdigitoxoside

Digoxigenin bisdigitoxoside is an anticancer agent and an active derivative of cardiac glycosides. Cardiac glycosides exert their apoptotic effects through the Nur77-dependent apoptotic pathway. Digoxigenin bisdigitoxoside is cytotoxic[1].

Product Specifications

CAS Number

[5297-05-2]

UNSPSC

12352005

Hazard Statement

H300

Target

Nuclear Hormone Receptor 4A/NR4A

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/digoxigenin-bisdigitoxoside.html

Solubility

10 mM in DMSO

Smiles

O[C@@]12[C@@]([C@](C3=CC(OC3)=O)([H])CC1)([C@@H](C[C@@]4([H])[C@@]2([H])CC[C@@]5([H])[C@@]4(CC[C@@H](C5)O[C@H]6C[C@@H]([C@@H]([C@H](O6)C)O[C@H]7C[C@@H]([C@@H]([C@H](O7)C)O)O)O)C)O)C

Molecular Formula

C35H54O11

Molecular Weight

650.80

Precautions

H300

References & Citations

[1]Li XS, et al. Synthesis of C3-Neoglycosides of digoxigenin and their anticancer activities. Eur J Med Chem. 2018 Feb 10;145:252-262.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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