RJW100
RJW100 is a potent liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1) agonist with pEC50s of 6.6 and 7.5, respectively[1]. RJW100 also causes strong activation of the miR-200c (miRNA-200c, microRNA-200c) promoter[2].
Product Specifications
CAS Number
[1276664-20-0]
UNSPSC
12352005
Target
MicroRNA
Type
Reference compound
Related Pathways
Epigenetics
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/rjw100.html
Purity
99.93
Solubility
10 mM in DMSO
Smiles
O[C@@H]1CC[C@@]2(C(C3=CC=CC=C3)=C)C(C4=CC=CC=C4)=C(CCCCCC)C[C@@]12[H]
Molecular Formula
C28H34O
Molecular Weight
386.58
References & Citations
[1]Richard J Whitby, et al. Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2) . J Med Chem. 2011 Apr 14;54 (7) :2266-81.|[2]Yuxia Zhang, et al. Regulation of miR-200c by nuclear receptors PPARα, LRH-1 and SHP. Biochem Biophys Res Commun. 2011 Dec 9;416 (1-2) :135-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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