Talaglumetad (hydrochloride)
Product Specifications
UNSPSC Description
Talaglumetad hydrochloride is a precursor of thetype II metabotropic glutamate receptor (mGluR2/3) agonist Eglumegad for the research of anxiety.
Target Antigen
mGluR
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/talaglumetad-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](N)C)N[C@]([C@@]1([H])[C@]2([H])[C@@H]1C(O)=O)(CC2)C(O)=O.Cl
Molecular Weight
292.72
References & Citations
[1]Kellner M, Muhtz C, Stark K, Yassouridis A, Arlt J, Wiedemann K. Effects of a metabotropic glutamate(2/3) receptor agonist (LY544344/LY354740) on panic anxiety induced by cholecystokinin tetrapeptide in healthy humans: preliminary results. Psychopharmacology (Berl). 2005;179(1):310-315. |[2]Varma MV, Eriksson AH, Sawada G, Pak YA, Perkins EJ, Zimmerman CL. Transepithelial transport of the group II metabotropic glutamate 2/3 receptor agonist (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY354740) and its prodrug (1S,2S,5R,6S)-2-[(2'S)-(2'-amino)propionyl]aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY544344). Drug Metab Dispos. 2009;37(1):211-220. |[3]Rorick-Kehn LM, Perkins EJ, Knitowski KM, et al. Improved bioavailability of the mGlu2/3 receptor agonist LY354740 using a prodrug strategy: in vivo pharmacology of LY544344. J Pharmacol Exp Ther. 2006;316(2):905-913.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-131286A/Talaglumetad-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-131286A/
Clinical Information
No Development Reported
CAS Number
441765-97-5
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS7098201-05 0.05 mg (Baculovirus)
Recombinant Conus ventricosus Conotoxin VnMEKL-0111
Ask
View Details