Talaglumetad (hydrochloride)

Talaglumetad hydrochloride is a precursor of thetype II metabotropic glutamate receptor (mGluR2/3) agonist Eglumegad for the research of anxiety.

Product Specifications

CAS Number

[441765-97-5]

Product Name Alternative

LY-544344 (hydrochloride)

UNSPSC

12352211

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/talaglumetad-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@H](N)C)N[C@]([C@@]1([H])[C@]2([H])[C@@H]1C(O)=O)(CC2)C(O)=O.Cl

Molecular Formula

C11H17ClN2O5

Molecular Weight

292.72

References & Citations

[1]Kellner M, Muhtz C, Stark K, Yassouridis A, Arlt J, Wiedemann K. Effects of a metabotropic glutamate (2/3) receptor agonist (LY544344/LY354740) on panic anxiety induced by cholecystokinin tetrapeptide in healthy humans: preliminary results. Psychopharmacology (Berl) . 2005;179 (1) :310-315. |[2]Varma MV, Eriksson AH, Sawada G, Pak YA, Perkins EJ, Zimmerman CL. Transepithelial transport of the group II metabotropic glutamate 2/3 receptor agonist (1S,2S,5R,6S) -2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY354740) and its prodrug (1S,2S,5R,6S) -2-[ (2'S) - (2'-amino) propionyl]aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY544344) . Drug Metab Dispos. 2009;37 (1) :211-220. |[3]Rorick-Kehn LM, Perkins EJ, Knitowski KM, et al. Improved bioavailability of the mGlu2/3 receptor agonist LY354740 using a prodrug strategy: in vivo pharmacology of LY544344. J Pharmacol Exp Ther. 2006;316 (2) :905-913.