Hydroxychloroquine Impurity E

Hydroxychloroquine Impurity E is the impurity of Hydroxychloroquine. Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro[1][2][3].

Product Specifications

CAS Number

[10500-64-8]

Product Name Alternative

4-[ (7-Chloro-4-quinolinyl) amino]-1-pentanol

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

SARS-CoV; Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Anti-infection; Immunology/Inflammation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/hydroxychloroquine-impurity-e.html

Purity

99.83

Solubility

10 mM in DMSO

Smiles

CC(NC1=CC=NC2=CC(Cl)=CC=C12)CCCO

Molecular Formula

C14H17ClN2O

Molecular Weight

264.75

Precautions

H302, H315, H319, H335

References & Citations

[1]Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4 (1) :6.|[2]Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85 (3) :429-40.|[3]Yao X, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) . Clin Infect Dis. 2020 Mar 9. pii: ciaa237.