Cetirizine Impurity C

Cetirizine Impurity C is an impurity of Cetirizine. Cetirizine, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist[1][2].

Product Specifications

CAS Number

[83881-59-8]

UNSPSC

12352005

Hazard Statement

H302-H312-H319-H335-H361-H400

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cetirizine-impurity-c.html

Solubility

10 mM in DMSO

Smiles

O=C(O)COCCN1CCN(C(C2=CC=CC=C2Cl)C3=CC=CC=C3)CC1

Molecular Formula

C21H25ClN2O3

Molecular Weight

388.89

Precautions

P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P391-P403+P233-P405-P501

References & Citations

[1]Shih MY, et al. Influence of cetirizine and levocetirizine on two cytokines secretion in human airway epithelial cells. Allergy Asthma Proc. 2008 Sep-Oct;29 (5) :480-5.|[2]Shimizu T, et al. Cetirizine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor: its potential anti-inflammatory action. Clin Exp Allergy. 2004 Jan;34 (1) :103-9.