Dihydro Donepezil

Dihydro Donepezil (Dihydro E2020) is a metabolite of Donepezil. Donepezil is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bAChE and hAChE, respectively[1].

Product Specifications

CAS Number

[120012-04-6]

Product Name Alternative

Dihydro E2020

UNSPSC

12352005

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dihydro-donepezil.html

Solubility

10 mM in DMSO

Smiles

OC1C(CC2CCN(CC3=CC=CC=C3)CC2)CC4=C1C=C(OC)C(OC)=C4

Molecular Formula

C24H31NO3

Molecular Weight

381.51

References & Citations

[1]Ogura, H., et al., Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol, 2000. 22 (8) : p. 609-13.