N-Boc-SBP-0636457-OH
N-Boc-SBP-0636457-OH, a ligand for E3 ubiquitin ligase, is used in the recruitment of IAP E3 ligases. N-Boc-SBP-0636457-OH can be connected to the ligand for Bcl-xL by a linker to form PROTAC Bcl-xL degrader-1 (HY-131188) .
Product Specifications
CAS Number
[2450350-79-3]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/n-boc-sbp-0636457-oh.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H]1CCCC2=C1C=CC(O)=C2)[C@@H]3C(C)(C[C@@]([H])(N3C4=O)OCC[C@@H]4NC([C@@H](N(C)C(OC(C)(C)C)=O)C)=O)C
Molecular Formula
C30H44N4O7
Molecular Weight
572.69
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Zhang X, et al. Discovery of IAP-recruiting BCL-XL PROTACs as potent degraders across multiple cancer cell lines. Eur J Med Chem. 2020;199:112397.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IAP
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