BACE-1 inhibitor 2
BACE-1 inhibitor 2 is a potent and CNS permeable BACE-1 inhibitor with an IC50 of 1.5 nM in BACE-1 enzymatic assay[1].
Product Specifications
CAS Number
2563970-92-1
UNSPSC
12352005
Target
Beta-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bace-1-inhibitor-2.html
Solubility
10 mM in DMSO
Smiles
[H][C@]12CC(F)(C(N)=N[C@@]1(C3=C(C=CC(NC(C4=NC=C(N=C4)OCF)=O)=C3)F)CO[C@@H](C)C2)F
Molecular Formula
C21H21F4N5O3
Molecular Weight
467.42
References & Citations
[1]Aldo Peschiulli , et al. 3,3-Difluoro-3,4,5,6-tetrahydropyridin-2-amines: Potent and Permeable BACE-1 Inhibitors. Bioorg Med Chem Lett. 2020 Apr 15;30 (8) :126999.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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