CDK6/9-IN-1
CDK6/9-IN-1 (compound 66) is an orally active active and dual CDK 6 and CDK 9 inhibitor, with IC50 values of 40.5 nM and 39.5 nM for CDK6 anmd CDK9, respectively[1].
Product Specifications
CAS Number
2414373-55-8
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk6-9-in-1.html
Solubility
10 mM in DMSO
Smiles
CC(NC1=CC=CC(NC2=NC(NC3=NC=C(N4CCN(C)CC4)C=C3)=NC=C2Cl)=C1)=O
Molecular Formula
C22H25ClN8O
Molecular Weight
452.94
References & Citations
[1]Yang Wang, et al. Discovery and SARs of 5-Chloro- N4-phenyl- N2- (pyridin-2-yl) pyrimidine-2,4-diamine Derivatives as Oral Available and Dual CDK 6 and 9 Inhibitors With Potent Antitumor Activity. J Med Chem. 2020 Mar 26;63 (6) :3327-3347.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK6; CDK9
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