Mytoxin B

Mytoxin B is an ADC cytotoxin. Mytoxin B is a satratoxin-type trichothecene macrolide and is similar to the effect of LY294002. Mytoxin B induces cell apoptosis via PI3K/Akt pathway[1].

Product Specifications

CAS Number

105049-15-8

UNSPSC

12352005

Target

ADC Payload; Apoptosis; PI3K

Type

Natural Products

Related Pathways

Antibody-drug Conjugate/ADC Related; Apoptosis; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mytoxin-b.html

Solubility

10 mM in DMSO

Smiles

CC1=C[C@](O[C@H]2[C@]3(OC3)[C@]4(C)[C@@H](C2)OC(/C=C/CC[C@@]5(C(C)=O)OCC/C([C@H]5O)=C/C(OC6)=O)=O)([H])[C@]46CC1

Molecular Formula

C29H36O9

Molecular Weight

528.59

References & Citations

[1]Huiliang Song, et al. Mytoxin B and Myrothecine A Induce Apoptosis in Human Hepatocarcinoma Cell Line SMMC-7721 via PI3K/Akt Signaling Pathway. Molecules. 2019 Jun 20;24 (12) :2291.