5-[ (2-Nitrophenyl) methylene]-2,4-thiazolidinedione

5-[ (2-Nitrophenyl) methylene]-2,4-thiazolidinedione (Compound 4) has antimicrobial, anti-diabetic and antioxidant activities. 5-[ (2-Nitrophenyl) methylene]-2,4-thiazolidinedione inhibits B. subtilis, S. aureus, K. pneumonia, E. coli, and S. typhi with MICs of 4.5-9.9 μΜ/mL, and inhibits A. niger and C. albicans with MICs of 4.99 μΜ/mL[1].

Product Specifications

CAS Number

[36140-65-5]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Bacterial; Fungal

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/5-2-nitrophenyl-methylene-2-4-thiazolidinedione.html

Solubility

10 mM in DMSO

Smiles

O=C(NC/1=O)SC1=C\C2=CC=CC=C2[N+]([O-])=O

Molecular Formula

C10H6N2O4S

Molecular Weight

250.23

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Elkamhawy A, et al. Thiazolidine-2,4-dione-based irreversible allosteric IKK-β kinase inhibitors: Optimization into in vivo active anti-inflammatory agents. Eur J Med Chem. 2020 Feb 15;188:111955.