NLRP3-IN-NBC6
NLRP3-IN-NBC6 is a potent, selective NLRP3 inflammasome inhibitor (IC50= 574 nM) that acts independently of Ca2+. NLRP3-IN-NBC6 inhibits Nigericin (HY-127019) -induced inflammasome activation in THP-1 cells and Imiquimod (HY-B0180) -induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs) [1].
Product Specifications
CAS Number
[2068818-02-8]
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nlrp3-in-nbc6.html
Purity
99.40
Solubility
10 mM in DMSO
Smiles
CC(C1=C(N[B-](C2=CC=CC=C2)([O+]=C1N)C3=CC=CC=C3)C(Cl)(Cl)Cl)=O
Molecular Formula
C18H16BCl3N2O2
Molecular Weight
409.50
References & Citations
[1]Baldwin AG, et al. Boron-Based Inhibitors of the NLRP3 Inflammasome. Cell Chem Biol. 2017;24 (11) :1321-1335.e5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NLRP3
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